RECOMBINANT STRAIN OF INFLUENZA VIRUS A/PR8-NS124-TB10_4-2A-HSPX AND METHOD FOR SPECIFIC PREVENTION OF PULMONARY TUBERCULOSIS USING MUCOSAL VACCINE BASED THEREON

摘要

FIELD: biotechnology.;SUBSTANCE: invention relates to the field of biotechnology. Invention represents a method for preparing the original vaccine strain and a method for specific prevention of pulmonary tuberculosis by means of a mucosal vector vaccine based thereon. Vaccine strain A/PR8-NS124-TB10.4-2A-HspX is produced on the basis of influenza virus with shortened NS1 protein and heterologous insert coding full-size antigens TV10.4 and HspX M.tuberculosis.;EFFECT: routine of preventive prime-immunization, involving primary BCG immunization and boosting intranasal immunization with an original vector vaccine based on strain A/PR8/NS124-TB10_4-2A-HspX, provides a protective effect substantially exceeding the protective effect of the BCG vaccine on the main indicators of the severity of the tuberculous infection.;2 cl, 8 dwg, 7 ex