METHODS FOR SELECTING A T-CELL LINE AND ITS DONOR FOR ADOPTIVE CELL THERAPY

摘要

FIELD: immunology.;SUBSTANCE: disclosed is a method of selecting an allogenic T-cell line, comprising selecting a T-cell line using representation, which identifies a plurality of HLA alleles and describes signs of relative activities of T-cell lines, each of which recognizes an epitope of a malignant tumor antigen and is limited by different versions of HLA alleles or combinations of HLA alleles, wherein in representation, each identified HLA allele or a combination of HLA alleles are associated with a corresponding feature of the relative activity of a T-cell line limited by a HLA allele or a combination of HLA alleles.;EFFECT: present method can be used in adoptive cancer therapy.;22 cl, 1 dwg, 6 tbl, 1 ex