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Degradable antimicrobial polymers

机译:可降解的抗菌聚合物

摘要

The invention relates to synthesis and characterization of cleavable and antimicrobially active polyions based on two amino alcohols and acid chlorides. One hundred percent of all polymers could be chemically saponified using a NaOH solution. It was also possible to carry out a five to twenty percent hydrolysis on y, x, y polyester, in particular on 3,6,3 polyester. In addition to chemical hydrolysis, the 3,6,3-polyester was enzymatically hydrolysed using Lipase B Candida antarctica. Minimum inhibitory concentration (MIC) tests were performed for all y, x, y polyester. It was noticed that an extension in the acid chloride resulted in a difference in the MIC values. The more hydrophobic the polymer, the better the MIC values were against both germs.
机译:本发明涉及基于两种氨基醇和酰氯的可裂解和抗微生物活性聚离子的合成和表征。可以使用NaOH溶液对所有聚合物中的100%进行化学皂化。还可以对y,x,y聚酯,特别是对3,6,3聚酯进行5%至20%的水解。除了化学水解以外,还使用脂肪酶B南极假丝酵母(Candida antarctica)将3,6,3-聚酯进行酶水解。对所有y,x,y聚酯均进行了最小抑菌浓度(MIC)测试。注意到酰基氯的延伸导致MIC值的差异。聚合物疏水性越强,对两种细菌的​​MIC值越好。

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