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'MULTI-TARGET' COMPOUNDS INHIBITORING HISTONE-DESACETYLASES AND POLYMERIZATION OF TUBULIN FOR USE IN THE TREATMENT OF CANCER
'MULTI-TARGET' COMPOUNDS INHIBITORING HISTONE-DESACETYLASES AND POLYMERIZATION OF TUBULIN FOR USE IN THE TREATMENT OF CANCER
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机译:抑制组蛋白去乙酰化和微管蛋白聚合的“多靶点”化合物,用于治疗癌症
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摘要
The present invention relates to the design of novel so-called “multi-target” molecules possessing a double pharmacophore and acting both as inhibitors of histone deacetylases (HDACs) and as inhibitors of the polymerization of tubulin. The invention also describes the process for synthesizing “multi-target” molecules and their application in the treatment of cancer, a pharmaceutical composition comprising at least one “multi-target” molecule, as well as the use of such compositions in the treatment. cancer.
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