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一种含有二苯甲烷结构的化合物及其应用

机译:一种含有二苯甲烷结构的化合物及其应用

摘要

Disclosed are a compound containing a diphenylmethane structure and a use thereof, belonging to the technical field of compound and polypeptide synthesis. The structure of the compound containing a diphenylmethane structure of the present invention is represented by general formula (1). The compound containing a diphenylmethane structure of the present invention contains a hydroxyl, an amino group, a substituted amino group, and an active group, and can be used as an amino acid or a peptide C-terminal protection reagent. A peptide synthesis reaction using this protection carrier has a fast reaction speed and a high reagent utilization rate in a suitable solvent system; post-treatment is carried out by means of simple liquid-liquid extraction separation, i.e. effective purification can be carried out, and finally, a product with a high purity can be obtained; and during a synthesis process, the change in solubility is small and an operation process has a strong universality, and therefore, the present method can be developed into a universal production method.
机译:公开了一种含有二苯甲烷结构的化合物及其用途,属于化合物和多肽合成技术领域。本发明的含有二苯基甲烷结构的化合物的结构由通式(1)表示。本发明的具有二苯甲烷结构的化合物含有羟基,氨基,取代的氨基和活性基团,可以用作氨基酸或肽的C末端保护剂。使用这种保护载体的肽合成反应在合适的溶剂体系中反应速度快,试剂利用率高。通过简单的液-液萃取分离进行后处理,即可以进行有效的纯化,最后得到高纯度的产物。并且在合成过程中,溶解度变化小,操作过程具有很强的通用性,因此,本方法可以发展为通用的生产方法。

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