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Anticarcinogenic composition comprising an inhibitor of DRG2 as an active ingredient

机译:包含DRG2抑制剂作为有效成分的抗癌组合物

摘要

The present invention relates to an anticancer composition comprising a DRG2 inhibitor as an active ingredient, an inhibitor of expression of a DRG2 (Developmentally regulated GTP-binding protein 2) gene according to the present invention or an inhibitor of activity of a DRG2 protein inhibits cell migration, Since it can effectively inhibit the metastasis of cancer cells by a mechanism that inhibits Rac 1 activity and inhibits VE-cadherin protein expression, an inhibitor of expression of the developmentally regulated GTP-binding protein 2 (DRG2) gene or an inhibitor of activity of the DRG2 protein It will be useful as an anti-cancer composition that can block the metastasis of cancer.
机译:本发明涉及一种抗癌组合物,其包含作为活性成分的DRG2抑制剂,根据本发明的DRG2(发育调节的GTP结合蛋白2)基因的表达抑制剂或DRG2蛋白的活性抑制剂抑制细胞。迁移,因为它可以通过抑制Rac 1活性并抑制VE-钙黏着蛋白表达的机制有效抑制癌细胞的转移,因此它是发育受调节的GTP结合蛋白2(DRG2)基因表达的抑制剂或活性的抑制剂。 DRG2蛋白的合成将用作可阻止癌症转移的抗癌组合物。

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