Peptide Inhibiting TLR4 Signaling Pathway and Uses Thereof

摘要

The present invention relates to a peptide that inhibits the TLR4 (Toll-like receptor 4) signaling pathway, and more specifically, binds to the TIR domain of TLR4, inhibits the secretion of pro-inflammatory cytokines, and activates NF-κB and MAPKs A peptide for inhibiting, a fusion peptide having a cell permeable peptide bound to the peptide, a TLR4 antagonist comprising the peptide or fusion peptide, and a composition for preventing or treating an autoimmune disease or inflammatory disease comprising the peptide or fusion peptide will be. The peptide according to the present invention exhibits an inhibitory effect on TLR4 and TLR3 signaling, blocks MyD88- and TRIF-dependent TLR4- pathways in many human and mouse cell lines, and is a substantial disease in rheumatoid arthritis, psoriasis and systemic lupus erythematosus mouse models Since it has a relaxing effect, it can be used as a therapeutic agent for immune-related diseases that require negative regulation of TLR.