Genetically modified mice expressing human apoE4 and mouse trem2p.r47h, and their use

摘要

With the expression of human apoE 4P and mouse trem2pGenetically modified mice characterized by one or more symptoms or symptoms associated with non familial delayed Alzheimer's diseaseMouse genome1) DNA sequences encoding the human apoE 4 protein (apoE 4P) operably connected to the promoterAnd 2) operatively connected to the promoterContains a DNA sequence encoding a mouse TREM2 protein (trem2p) with a p.r47h mutation.This causes the mouse toExpressing human apoE 4P and mouse trem2pGenetically modified mice are provided.Such genetically modified mice are used to provide a method for screening compounds for use in the treatment of Alzheimer's disease.