Novel Patient-derived Xenograft Model of Glioblastoma and Use thereof

摘要

The present invention relates to a new glioblastoma patient-derived xenograft model and its preparation and use, and more specifically, to a glioblastoma patient-derived xenograft model that enables quick selection of treatment options in treating glioblastoma with a short average survival time. And its manufacturing method and a method for selecting a patient-specific glioblastoma treatment using the same. The patient-derived xenograft animal model of glioblastoma according to the present invention retains the characteristics of the original tumor. In addition, even in patients with glioblastoma cells that do not form intracranial tumors with the allograft method, even the average time from initial surgery to relapse in glioblastoma patients is considered even when the preparation period of patient-derived cells is considered by forming tumors within 4 weeks. Treatment options can be screened within a much shorter six weeks. In addition, the patient-derived xenograft animal model of glioblastoma according to the present invention is an effective alternative by simulating the microenvironment of the brain, unlike the glioblastoma model implanted subcutaneously. In addition, it can be easily monitored by using the naked eye or simple indirect ophthalmoscope, etc. without additional equipment, and a relatively small number of glioblastoma cells are required to produce a glioblastoma model. useful.