Analogue of pyruphenide and pyridone of aerosols and their use

摘要

Problem to be solved: to provide a formulation for the aerosol administration of an analog compound of pyrufenide or pyridon for prevention or treatment of various fibrosis and inflammatory diseases.Solution: a daily dose for reducing the IL-1 beta level in the lungs of adults diagnosed with pulmonary fibrosisThe daily dose wasAerosol suitable for inhalation formed by spray of aqueous solution of pyruphenidePyrufenide has a concentration of about 0.1 to about 20 mg \/ mlCitric acid sodium saltCitric acidSodium chlorideContains sodium and saccharin sodiumMolar ratio of sodium saccharin to pyreneOsmotic pressure of the aqueous solutionAnd the pH of the solution is a specific range, respectivelyThe administration to the adult lowers the IL-1 beta level in the bronchoscopic fluid at leastDaily dose.Diagram