Molecular probes for double target imaging and their preparation methods and Applications

摘要

The tate-rgd double target polypeptide drug of the present invention allows simultaneous binding of somatostatin receptors and integrins. Alpha. V.beta. 3, has higher binding affinity and tumor uptake, has better non target tissue clearance rates, and has better bioin and in vitro stability.The present invention provides methods and applications for the preparation of said compound and said radioactive probe.The present invention provides a tumor targeting polypeptide compound having a dual target.The structure comprises a ate cyclic peptide structure, an RGD cyclic peptide structure, and a NO.sub.x chelating group, wherein the Tate cyclic peptide structure, the RGD cyclic peptide structure, and the NO.sub.x chelate group are bonded directly to the same glutamate molecule via PEG segments having a degree of polymerization of 1 to Combine.The structure of the polypeptide compound is represented as nota-pegn Glu {pegm-tate} - pegp-rgd, and m, N, P take an integer of 0 to 5, respectively.Further, the present invention provides a tate-rgd double gradient molecular probe.