Joint estimation of respiratory parameters by regional fitting of respiratory parameters

摘要

Receiving a measurement of the pressure of air inhaled or exhaled by a ventilator-equipped patient (12) operatively connected to the medical ventilator (10) Receiving air flow measurements into or out of a ventilated patient operatively connected to a medical ventilator; breathing time intervals into a plurality of fitting regions (60); And simultaneously estimating the respiratory system resistance and compliance or elastic modulus and respiratory muscle pressure in each fitting region by fitting a time series of pressure and air flow samples in that fitting region; A medical ventilator performing a method comprising. In one approach, fitting includes parameterizing respiratory muscle pressure with a continuously differentiable function, such as a polynomial function over the fitting region. In another approach, the fitting is for the pulmonary equation of motion in each fitting region, limiting monotonic constraints, and at least respiratory muscle pressure Pmus (t), and respiratory system resistance R and compliance C Inequalities apply to respiratory muscle pressure in each region.