Modulators of PGI2 receptors useful in the treatment of disorders associated with prostacyclin (PGI2) receptors

摘要

PROBLEM TO BE SOLVED: To provide a modulator of PGI2 receptor useful for treating a disorder related to prostacyclin (PGI2) receptor. A compound, for example, formula (XIIIa) and pharmaceutical compositions thereof are as follows: pulmonary arterial hypertension (PAH); idiopathic PAH; familial PAH; collagen vascular disease, congenital heart disease, portal hypertension, PAH associated with HIV infection, drug or toxin uptake, hereditary hemorrhagic telangiectasia, splenectomy, pulmonary vein obstructive disease (PVOD), or pulmonary capillary hemangiomatosis (PCH); predominantly venous or capillary PAH with involvement; platelet aggregation; coronary artery disease; myocardial infarction; transient cerebral ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; angioplasty or coronary bypass surgery Useful for treating clot formation in an individual or an individual suffering from atrial fibrillation; atherosclerosis; atherosclerosis; asthma or its symptoms. [Selection diagram] None