BIBLIOTHÈQUES DYNAMIQUE D'ANTICORPS HUMAINS À CHAÎNE LOURDE

摘要

Provided herein are libraries containing polynucleotides， where one of the polynucleotides encodes an antibody heavy chain with specific hypervariable regions HVR-H1 and HVR-H2. Further provided herein are libraries containing polynucleotides encoding a plurality of unique antibodies， wherein each antibody comprises a heavy chain variable region and a light chain variable region. Also provided are antibodies， polypeptide libraries， vector libraries， cells， non-human animals， antibody heavy chains， methods of making an antibody library， kits， and methods of generating a bispecific antibody related thereto.