COMPOSÉS ET MÉTHODES DE MODULATION DE L'EXPRESSION DE L'ALIPOPROTÉINE C-III POUR AMÉLIORER LE PROFIL DIABÉTIQUE

摘要

Provided herein are improved compounds, compositions and associated methods for reducing expression of ApoCIII mRNA and protein in a subject having, or at risk of having, diabetes. Also provided herein are compounds, compositions and associated methods improving peripheral insulin sensitivity, a lipid profile and a diabetes profile as well as reducing free fatty acids and intramyocellular triglyceride deposition.