ANALYSE D'UN POLYMÈRE COMPRENANT DES UNITÉS POLYMÈRES PAR TRANSLOCATION À TRAVERS UNE NANOPORE

摘要

A polymer comprising polymer units is analysed by: during translocation of a polymer through a nanopore while a voltage is applied across the nanopore, making measurements that are dependent on the identity of k-mers in the nanopore, a k-mer being k polymer units of the polymer, where k is a positive integer, wherein the measurements comprise, (i) in respect of individual k-mers, or (ii) in respect of analysis performed on the input signal itself, separate measurements made at different levels of said voltage applied across the nanopore; and analysing the measurements at said different levels of said voltage to determine the identity of at least part of the polymer.