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RÉGIME POSOLOGIQUE POUR L'ADMINISTRATION D'UN ANTICORPS BISPÉCIFIQUE CD19XCD3 À DES PATIENTS À RISQUE D'ÉVENTUELS EFFETS INDÉSIRABLES
RÉGIME POSOLOGIQUE POUR L'ADMINISTRATION D'UN ANTICORPS BISPÉCIFIQUE CD19XCD3 À DES PATIENTS À RISQUE D'ÉVENTUELS EFFETS INDÉSIRABLES
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摘要
A method for assessing the risk of potential adverse effects for a human patient receiving a CD19×CD3 bispecific antibody is provided. The method comprises determining the total B count in the patient, and identifying a B cell number indicative of a patient at risk of potential adverse effects from the antibody. The method further provides a dosing schedule for administering the antibody to the patient identified as at risk of potential adverse effects. Also provided is a pharmaceutical package or kit comprising a first dose and a second dose, and optionally a third dose, of the CD19×CD3 bispecific antibody as defined in the methods/dosage regimen of the disclosure.
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