TISSU DE TENDON OU DE LIGAMENT ARTIFICIEL PRODUIT AU MOYEN D'UN SYSTÈME DE CULTURE DE CELLULES À MÉCANOSIGNALISATION TRIDIMENSIONNELLE

摘要

The present invention relates to providing artificial tendon or ligament tissue having sufficient strength. More specifically, artificial tendon or ligament tissue having sufficient strength is provided by embedding collagen-secreting cells in a gel having strength capable of resisting a tensile load and by culturing the cells while applying a tensile load to the gel to produce artificial tendon or ligament tissue. Cells that steadily express the Mkx gene can be used as the collagen-secreting cells. A fibrin gel containing aprotinin can be used as the gel.