5-(1-cyano-1-alkyl-N-methyl-N-methoxy-phenethyl)-alkylamino-2,2,8- trimet hyl- 4H-dioxino-(4,5-c)-pyridine derivatives, and their use as calcium antagonistic agents

摘要

The invention relates to new 5-(1-cyano-1-alkyl-N-methyl-N-methoxy-phenethyl)-alkylamino-2,2,8-trim ethyl-4H-dioxino-(4,5-c)-pyridine derivatives of the formula and therapeutically acceptable salts of these compounds, to a preparation process of the same comprising reacting, in stoichiometric proportions, the corresponding 5-(1-cyano-1-R1)-methyl-2,2,8-trimethyl-4H-dioxino-(4,5-c)-pyridine of the formula on the appropriate [N-methyl-N-(methoxy-phenethyl)]- omega -alkyl chloride of the formula The invention relates also to therapeutic compositions containing said derivatives as active ingredients.