CORONAVIRUS VIVANT ATTÉNUÉ COMPRENANT UN GÈNE DE RÉPLICASE VARIANT CODANT POUR DES POLYPROTÉINES COMPRENANT UNE MUTATION DANS NSP-10.

摘要

The present invention provides a live, attenuated coronavirus comprising a variant replicase gene encoding polyproteins comprising a mutation in one or more of non-structural protein(s) (nsp)-10, nsp-14, nsp-15 or nsp-16. The coronavirus may be used as a vaccine for treating and/or preventing a disease, such as infectious bronchitis, in a subject.