APPLICATION DE PARNI LNCRNASENST00000607393 DANS LA PRÉPARATION D'UNE PRÉPARATION POUR LE TRAITEMENT DU GLAUCOME

摘要

The present invention is directed to provide application of lncRNAs ENST00000607393 SiRNA in preparation of a preparation for treating glaucoma. The present invention clarifies the correlation between the expression level of ENST00000607393 and the calcification of human primary trabecular meshwork cells. The expression level of ENST00000607393 in human primary trabecular meshwork cells is firstly down-regulated to 46.21% of a control group by siRNA interference. Under the condition of intervening with the cells by a 500 µmol/L hydrogen peroxide solution for 48 hours, it is observed that compared with the control group, the down-regulation of ENST00000607393 expression can significantly decrease the ALP activity in human primary trabecular meshwork cells, and thus significantly decrease the calcification level of human primary trabecular meshwork cells to play a role of treating or preventing glaucoma.