COMPOSITIONS POUR INDUIRE LA DIFFÉRENCIATION DE CELLULE SUPPRESSIVES DÉRIVÉES DE MYÉLOÏDE POUR TRAITER LE CANCER ET LES MALADIES INFECTIEUSES

摘要

The present invention pertains to the field of immunotherapy. More specifically, the present invention provides a method for differentiating myeloid-derived suppressor cells (MDSC) into non suppressive cells, by administering a compound blocking the interaction between SIRPa and CD47 to a patient in need thereof, in order to reduce MDSC-induced immunodepression and consequently allow appropriate immune responses in cancers, infectious diseases, vaccination, trauma, autoimmune diseases, chronic inflammatory diseases and transplantation.