COMPOSITIONS ET PROCÉDÉS PERMETTANT D'INDUIRE L'APOPTOSE DANS DES CELLULES ANAÉROBIES ET PROCÉDÉS CLINIQUES ASSOCIÉS POUR LE TRAITEMENT DU CANCER ET D'INFECTIONS PATHOGÈNES

摘要

The invention provides potent anti-cancer methods and compositions that employ novel glycome compounds exemplified by glyco-benzaldehydes that disrupt anaerobic respiration and trigger apoptosis in cancer cells. Additionally, the invention provides useful compositions and methods to treat viral and microbial infections, and for enhancing suppressed immune systems, including by disrupting alpha-N-acetylgalactosaminidase (nagalase) function and lov/ering circulating nagalase blood levels. In certain anti-cancer and immune enhancing methods and compositions of the invention glyco-benzaldehyde compounds, such as the plant-deri ved glyco- benzaldehyde helicidum, are employed, alone or in combination, to potently destroy tumors and c irculating cancer cells, and significantly prolong survival of cancer patients, including treatment-resistant Stage III and Stage IV cancer patients.