COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE PATIENTS SOUFFRANT DE GLIOME OU DE LEUCÉMIE

摘要

Pharmaceutical compositions, kits and methods for treating tumors such as glioma and cancers such as leukemia with (R)-2-hydroxyglutarate (R-2HG) are provided, along with therapeutic regimens including treatment of a patient suffering from glioma or leukemia with a MYC-signaling inhibitor followed by or cotemporaneous with treatment with R-2HG, and optionally other chemotherapeutic agents.