PROCÉDÉ POUR PRÉPARER DES DÉRIVÉS DE 2,3-DIHYDRO-1H-INDÉN-1-ONE EN TANT QU'ANTAGONISTES DU RÉCEPTEUR ORPHELIN GAMMA APPARENTÉ AU RÉCEPTEUR DE L'ACIDE RÉTINOÏQUE (ROR GAMMA) POUR LE TRAITEMENT DE LA SCLÉROSE EN PLAQUES

摘要

The present invention is directed to the synthesis of compounds of formula (I) useful for modulating RORγt/RORγ activity and for treating diseases or conditions mediated by RORγt/RORγ and thus disease states associated with immunopathology of human autoimmune diseases such as Multiple Sclerosis (MS), Rheumatoid Arthritis (RA), Inflammatory Colitis, Psoriasis, COPD, Pain, Obesity, Diabetes, Dyslipidemia, Osteoporosis, Asthma, Neurodegenerative diseases and Cancer.