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UTILISATION DE MICROCYSTINES DANS LA PRÉPARATION DE MÉDICAMENTS POUR LA PRÉVENTION OU LE TRAITEMENT DE MALADIES DE FIBROSE D'ORGANE ET DE TISSU
UTILISATION DE MICROCYSTINES DANS LA PRÉPARATION DE MÉDICAMENTS POUR LA PRÉVENTION OU LE TRAITEMENT DE MALADIES DE FIBROSE D'ORGANE ET DE TISSU
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摘要
Use of microcystins having a monocyclic heptapeptide structure in preparation of drugs for preventing or treating organ and tissue fibrosis diseases. Preferably, the microcystins are microcystin-LR with amino acids at positions 2 and 4 of a monocyclic heptapeptide structure thereof being leucine and arginine respectively, or are microcystin-RR with amino acids at positions 2 and 4 thereof being both arginine. Also provided is a method for inhibiting myofibroblast differentiation and collagen synthesis. The method is implemented by inhibiting a TGF-β/Smad signaling pathway by using one or more microcystins.
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