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INHIBITEURS DE SMAC/DIABLO UTILES DANS LE TRAITEMENT DU CANCER
INHIBITEURS DE SMAC/DIABLO UTILES DANS LE TRAITEMENT DU CANCER
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摘要
The present invention relates to compositions and methods for treating cancer, particularly to agents that inhibit the expression and/or activity of the protein second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low p I (SMAC/Diablo). The inhibiting agents include RNA interference molecules silencing the expression of SMAC/Diablo and peptides modulating its interactions within the cell nucleus and mitochondria. The methods and agents of the present invention are useful in treating cancers associated with overexpression of SMAC/Diablo.
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