COMPOSITION COMBINÉE POUR LA PRÉVENTION OU LE TRAITEMENT DU CANCER COMPRENANT DES DÉRIVÉS DE BENZOPHÉNONE THIAZOLE EN TANT QUE VDA ET UN INHIBITEUR DE TOPO-ISOMÉRASE

摘要

The present invention relates to a pharmaceutical combined composition for preventing or treating cancer comprising a compound of formula 1 or a pharmaceutically acceptable salt thereof and topoisomerase inhibitor as active ingredients. The pharmaceutical combined composition of the present invention specifically inhibits cell proliferation and induces apoptosis as to various cancers such as colorectal cancer and ovarian cancer that a vascular disrupting agent cannot treat due to a complex inhibition mechanism of neoplasm of the compound of formula 1 and the pharmaceutically acceptable salt thereof and topoisomerase inhibitor, and thereby it can be usefully used for preventing and treating cancer.