Beneficial effect of high energy intake at lunch rather than dinner on weight loss in healthy obese women in a weight-loss program: a randomized clinical trial

摘要

ABSTRACTudBackground: The association between the time of nutrient intake and health has been described in a few studies. To our knowledge, no study has evaluated the relation between high energy intakes at lunch compared with at dinner on weight loss in overweight and obese subjects.udObjective: We compared the effect of high energy intake at lunch with that at dinner on weight loss and cardiometabolic risk factors in women during a weight-loss program.udDesign: Overweight and obese women [n = 80; body mass indexud(BMI; in kg/m2): 27–35; age: 18–45 y] were asked to eat either a main meal at lunch (LM) or a main meal at dinner (DM) for 12 wk while in a weight-loss program.udResults: A total of 80 participants were randomly assigned to one of 2 intervention groups. Sixty-nine subjects (86%) completed the trial (34 subjects in the DM group, and 35 subjects in the LM group). Baseline variables were not significantly different between groups. A significant reduction in anthropometric measurements and significantudimprovements in cardiometabolic risk characteristics were observed over 12 wk in both groups. Compared with the DM group, the LM group had greater mean 6 SD reductions in weight (LM: 25.85 6 1.96 kg; DM: 24.35 6 1.98 kg; P = 0.003), BMI (LM: 2.276 0.76; DM: 1.68 6 0.76; P = 0.003), homeostasis model assessment of insulin resistance (LM: 20.66 6 0.33; DM: 20.46 6 0.24; P = 0.001), and fasting insulin (LM: 22.01 6 1.10 mIU/mL; DM: 21.16 6 0.72 mIU/mL; P , 0.001) after 12 wk. However, there were no significant differences for fasting plasma glucose and lipid profilesudwithin both groups after 12 wk.udConclusions: The consumption of higher energy intake at lunch compared with at dinner may result in favorable changes in weight loss in overweight and obese women after a weight-loss program of 12 wk. The consumption may also offer clinical benefits to improve insulin resistance. This trial was registered at clinicaltrials.gov as NCT02399280. Am J Clin Nutr doi: 10.3945/ajcn.116.134163.