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Position paper: management of perforated sigmoid diverticulitis.

机译:立场文件:乙状结肠憩室穿孔的治疗。

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摘要

Over the last three decades, emergency surgery for perforated sigmoid diverticulitis has evolved dramatically but remains controversial. Diverticulitis is categorized as uncomplicated (amenable to outpatient treatment) versus complicated (requiring hospitalization). Patients with complicated diverticulitis undergo computerized tomography (CT) scanning and the CT findings are used categorize the severity of disease. Treatment of stage I (phlegmon with or without small abscess) and stage II (phlegmon with large abscess) diverticulitis (which includes bowel rest, intravenous antibiotics and percutaneous drainage (PCD) of the larger abscesses) has not changed much over last two decades. On the other hand, treatment of stage III (purulent peritonitis) and stage IV (feculent peritonitis) diverticulitis has evolved dramatically and remains morbid. In the 1980s a two stage procedure (1st - segmental sigmoid resection with end colostomy and 2nd - colostomy closure after three to six months) was standard of care for most general surgeons. However, it was recognized that half of these patients never had their colostomy reversed and that colostomy closure was a morbid procedure. As a result starting in the 1990s colorectal surgical specialists increasing performed a one stage primary resection anastomosis (PRA) and demonstrated similar outcomes to the two stage procedure. In the mid 2000s, the colorectal surgeons promoted this as standard of care. But unfortunately despite advances in perioperative care and their excellent surgical skills, PRA for stage III/IV diverticulitis continued to have a high mortality (10-15%). The survivors require prolonged hospital stays and often do not fully recover. Recent case series indicate that a substantial portion of the patients who previously were subjected to emergency sigmoid colectomy can be successfully treated with less invasive nonoperative management with salvage PCD and/or laparoscopic lavage and drainage. These patients experience a surprisingly lower mortality and more rapid recovery. They are also spared the need for a colostomy and do not appear to benefit from a delayed elective sigmoid colectomy. While we await the final results ongoing prospective randomized clinical trials testing these less invasive alternatives, we have proposed (based primarily on case series and our expert opinions) what we believe safe and rationale management strategy.
机译:在过去的三十年中,针对乙状结肠憩室穿孔的急诊手术已取得了巨大进展,但仍存在争议。憩室炎分为不复杂(适合门诊治疗)和复杂(需要住院)。患有复杂憩室炎的患者接受计算机断层扫描(CT)扫描,并使用CT检查结果对疾病的严重程度进行分类。在过去的二十年中,I期(有或没有小脓肿的痰)和II期(有大脓肿的痰)憩室炎(包括肠脓肿,静脉内抗生素和较大脓肿的经皮引流(PCD))的治疗没有太大变化。另一方面,III期(化脓性腹膜炎)和IV期(剧烈的腹膜炎)憩室炎的治疗已显着发展并且仍然是病态的。在1980年代,对于大多数普通外科医师而言,分两个阶段进行手术(第一节–乙状结肠段结肠切除术,第二节–第三至六个月后结肠造瘘术关闭)。但是,已经认识到这些患者中有一半从未进行过结肠造口术,并且结肠造口术关闭是一种病态过程。结果,从1990年代开始,结直肠外科专家不断增加,进行了一个阶段的初级切除吻合术(PRA),并显示出与两个阶段手术相似的结果。在2000年代中期,大肠外科医生将其推广为护理标准。但是,不幸的是,尽管围手术期护理有所进步,并且具有出色的手术技能,但用于III / IV期憩室炎的PRA仍然具有较高的死亡率(10-15%)。幸存者需要长时间住院,并且常常不能完全康复。最近的病例系列表明,以前曾接受过紧急乙状结肠切除术的患者中,相当一部分患者可以采用抢救性PCD和/或腹腔镜灌洗和引流术,以较少的非手术性非手术治疗得以成功治疗。这些患者的死亡率令人惊讶地降低,康复速度更快。他们也不必进行结肠造口术,并且似乎不会从延迟的选择性乙状结肠切除术中受益。在等待最终结果的同时,正在进行的前瞻性随机临床试验正在测试这些侵入性较小的替代方案,同时我们(主要基于病例系列和专家意见)提出了我们认为安全和合理的管理策略的建议。

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