A FUNDAMENTAL STUDY ON RENAL CELL CARCINOMA PART4. CONCENTRATION OF POLYAMINES IN NEOPLASTIC RENAL TISSUE IN COMPARISON WITH NORMAL RENAL CORTEX

摘要

In order to obtain biochemical indicators for histopathological or biological malignancy of renal cell carcinoma, concentration of polyamines were measured in twenty-six cancerous tissues and nine normal renal cortexes. Results obtained were as followings. 1. The cancerous tissues contained higher amount of polyamines than normal renal tissues; putrescine and spermine levels were found to be approximately two-folds and spermidine was about four-folds of each compound in nomal renal tissues. 2. There was a statistically significant correlation between the level of spermidine and the histological grade of malignancy of the tumor. The ratio of spermidine/spermine was also proved to be biochemical indicator of histological malignancy. 3. No significant difference was detected in concentration of these compounds among the non-metastasis and distant-metastasis groups of renal cell carcinoma, as well as among the types of cytoplasmic staining property. These results suggested that the determination of polyamines, especially of spermidine, in urine or serum would be useful for the diagnosis or the evaluation of therapeutic modalities of renal cell carcinoma.