Drug-drug interactions in prescriptions of Lorestan province, Western of Iran

摘要

Rational prescribing means prescribing the more effective and healthiest drug for a disease according to patient’sudcondition, the type of effective drugs, cost and etc. The non-normative and non-rational prescribing of medicine canudcause side effects. Prescribing of effective and safe drugs can have an important role in treatment of patient and theudlack of side effect, drug interactions and imposition of additional cost. The aim of this study was to evaluate drugudinteractions in prescriptions of Lorestan province, western of Iran In this study, at first, the statistic of the insuranceudprescription of all provincial pharmacies were obtained, interred in the prescription review software of food anduddrug administration, processed in terms of drug interactions and data were statistically analyzed. This study showsudthat of the total 1443973 of the prescription numbers, 1112 numbers of that contain 1.25 mg of Digoxin tablets withud40 mg of Furosemide tablets that they have a severe interaction and can lead to arrhythmia in patients. Also 934udprescriptions contain Gemfibrozil and Lovastatin which can lead to myopathy and rhabdomyolysis in consumerudpatients. The survey revealed that 1.36, 3.76 and 0.56% of prescriptions have mild, moderate and severeudinteractions, respectively. Existence of severe and moderate drug interactions requires that further workshops beudheld for physicians on drug interactions.