Dermal Absorption of Methanol and Methanol/Gasoline Mixtures

摘要

The objective of this study was to determine the effect of dermally appliedmethanol/gasoline mixtures on 14C-methanol metabolism in Sprague-Dawley rats. Following applications of 100% methanol or methanol/gasoline mixtures (95, 90, 85, 50 or 5% methanol), methanol vapor, carbon dioxide, and excreta were collected, and the animals sacrificed to quantify levels of 14C in blood and major tissues. Mean dermal absorption efficiencies of methanol were 24.8, 31.6, 24.5, 27.0, 35.7 and 58.1% for the 100, 95, 90, 85, 50 and 5% methanol mixtures, respectively. Only the absorption efficiences of the 5% and 50% methanol mixtures were statistically significant relative to 100% methanol. A pharmacokinetic model was used to simulate the main aspects of methanol absorption and disposition.