Biotransformation of Quinoline and Methylquinolines in Anoxic Freshwater Sediment

摘要

Quinoline (Q) and some isomers of methylquinoline (MQ) were transformed tohydroxylated products in freshwater sediment slurries incubated under methanogenic conditions at 25 C. Methylquinoline transformation was not affected by a methyl group on the C-3 or C-4 carbon atom of the pyridine ring; 2-MQ, however, was not transformed. The transformations of Q and MQs were pH dependent with an optimal pH of 7-8. The results of the study suggest that two pathways may exist for the anaerobic transformation of quinoline; one pathway leads to the formation of a hydroxylated intermediate and the other to a methylated and hydroxylated intermediate. In addition, the results suggest that a methyl substituent on the number 2 carbon inhibits the anaerobic transformation of quinoline derivatives.