Wound Healing: The Effect of Supplemental Oxygen Therapy.

摘要

The purpose of this pilot study was to clarify tissue and healing requirements with regard to the clinical use of oxygen (timing, dose, duration). Tissue oxygen and wound healing effects of short term, and postoperative oxygen therapy were tested. Twenty four subjects having fusion of the cervical spine and/or excision of a cervical intervertebral disc were enrolled in a randomized, experimental repeated measures design. The treatment group (n=13) received 28% oxygen for the first 36 postoperative hours. The control group (n=11) was maintained on room air. Subcutaneous tissue oxygen (PscO2) and temperature (TGsc) were measured pre-treatment and at postoperative hours 1-4, 18 and 36 using a tonometer/oxygen electrode system. Wound healing was evaluated by hydroxyproline content in a subcutaneous polytetrafluoroethylene (ePTFE) tube removed on the 7th postoperative day. Clinical wound complications were evaluated using the ASEPSIS Wound Scoring System and postoperative medical record view.