Case-Cohort Study of Styrene Exposure and Ischemic Heart Disease

摘要

This case-cohort study explored a possible association and dose-response relation between styrene exposure and risk of acute Ischemic Heart Disease (IHD) in an occupational setting. The population under study was 6587 male workers employed between 1943 and 1982 in two US plants manufacturing styrene-butadiene polymers used in synthetic rubber. The study assessed all 498 subjects who died from IHD along with a subcohort of twice that size, 997 subjects, selected as a 15% random sample of the full target cohort.