Azidothymidine (AZT): Multigenerational Reproductive Assessment by Continuous Breeding when Administered to Swiss CD-1 (Trade Name) Mice by Gavage. Volume 1 of 2;Final rept

摘要

Azidothymidine (AZT) was evaluated for potential reproductive toxicity using the multigenerational continuous breeding paradigm. With the increasing prophylactic use of AZT comes concerns about the function of the offspring of treated parents. A dose-range finding study was conducted by administering AZT to adult male and female CD 1 mice twice daily by gavage using split doses of equal amounts approximately six hours apart to achieve a total daily dose of 0, 50, 100, or 200 mg/kg (N=8 adult mice/sex). Since there was no offspring lethality, and since previous studies had shown this high dose was effective at reducing sperm motility in mice, these dose levels were selected for the cohabitation.