Quantifying the Size of Ischemic, Infarcted and/or Scarred Myocardium-Methods Suitable for Use in Living Man. Identification of Regional Myocardial Perfusion Defects by Radioisotope Scintiscanning.

摘要

The purpose of this project was to develop scintigraphic methods for quantification of regional myocardial ischemia and infarction. Labeled potassium analogs and fatty acids experimentally have been used as flow indicators but potassium-43,cesium-219and carbon-11labeled fatty acids did not prove satisfactory clinically because of suboptimal physical characteristics. However,terminally iodinated hexadecenoic acid,tagged with iodine-123,now is being evaluated as a potentially applicable radiopharmaceutical. Detection of an ischemic defect alone is not sufficient in infarct evaluations as the age is not defined. Fortuitously, a number of radioactive agents tend to localize around acutely damaged myocardial tissue and produce 'positive'images. Of particular interest is a group of technetium-99m phosphate compounds. Although the information provided is not quantitative,this method,combined with the regional perfusion techniques,can be used to distinguish acute myocardial ischemia and injury from other causes of ischemia.