Mammalian Models for Research on Aging

摘要

The primary focus of this report is the relevance and appropriateness of selected mammals as models of human aging. Animal experimentation provides a scientifically valid and ethical approach to the development of new knowledge and contributes to human and animal welfare. In this sense, the scientific moral justification for using animals in research on aging is the same as for other areas of biomedical significance. Legal, ethical, and practical constraints limit the extent to which human subjects can be used in research on aging. Moreover, an understanding of human aging requires basic research on relevant biological principles and phenomena. Man is not an appropriate subject for much of this type of research. Accordingly, utilization of many biological systems and animal species is necessary to study the scientific questions that are relevant to human aging.