Workshop on Exposure to Environmental Agents, Their Metabolism, and Mechanisms of Toxicity: Research Needs

摘要

The report is the product of a workshop sponsored by the Task Force on Environmental Cancer and Heart and Lung Disease. It contains 72 recommendations for basic and applied environmental research, which were developed through a consensus of scientific experts from Government, industry and academia. Research needs are identified in the following areas: accessing Federal data systems for epidemiological research; improving analytical techniques for monitoring and assessing human exposures; understanding mechanisms of activation and detoxification of environmental pollutants in animals and humans; examining the interactions of environmental pollutants with macromolecules, such as DNA; and understanding the repair and replicative processes, and gene expression as possible common toxicological events in cancer and heart and lung disease.