Final Phase II Report of Task I Preclinical Intravenous Toxicity Study of N-Methylformamide (NSC 3051) in CD2F1 Mice and Beagle Dogs

摘要

In CD2F1 mice administered a single intravenous dose of N-methylformamide (NSC 3051) the day 29 LD10, LD50, and LD90 for combined sexes are 1167.73, 2308.53, and 4563.86 mg/kg (3503.19, 6925.59, and 13691.58 mg/sq. m). The combined sexes estimate for mice administered five consecutive daily doses are 441.22, 1336.85, and 4050.47 mg/kg/day (1323.66, 4010.55, and 12151.41 mg/sq. m/day). Male mice were more susceptible to the lethal effects of N-methylformamide in both studies.