Evaluation of the Potential Carcinogenicity of 1,2:3,4-Diepoxybutane (1464-53-5)

摘要

Diepoxybutane is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. Evidence on potential carcinogenicity from animal studies is 'Sufficient', and the evidence from human studies is 'No Data'. The potency factor (F) for diepoxybutane is estimated to be 28.0 (mg/kg/day)-1, placing it in potency group 2 according to the CAG's methodology for evaluating potential carcinogens. Combining the weight-of-evidence group and the potency group, diepoxybutane is assigned a 'MEDIUM' hazard ranking.