Hemolysis of Washed Rats Erythrocytes in vitro by Dust Particles with Cover Letter

摘要

Chronic toxicity was evaluated in 50 male Sprague-Dawley rats, and 15 male Syrian hamsters exposed to asbestos via inhalation at a nominal concentration of 85 mg/m3 for 7 months, followed by a lifetime observation period. In the exposed rat group, the pulmonary responses included alveolar adenomatous proliferation, non-progressive fibrosis, squamous metaplasia and a substantial incidence of pulmonary carcinoma formation (6/34). Mean body weight of exposed rats was significantly lower after 1 month of exposure, it remained low until 14 months post exposure. Mortality data for the rat group indicated no significant difference between exposed and control rats. Mortality in the exposed hamster group was significantly increased during the 7 month exposure period. No pulmonary neoplasms were noted in the surviving hamsters, (the ability to evaluate long-term pulmonary effects was severely limited due to early mortality of 8/15 hamsters). The mean body weight for hamsters was statistically decreased during the first month of exposure, but statistically increased and remained so for the remainder of the study. Histopathologic studies of other, non-pulmonary tissues were not significantly different from the control group for rats or hamsters. Document includes: Effects from Chronic Inhalation of Asbestos Pipe-covering Dust in Rats and Hamsters. Statistical Evaluation of Respiratory System Indicatiors among Insulators. A Statistical Evaluation of Respiratory System Indicators among Pipe Coverers.