Mechanical Stimulation of Skeletal Muscle Mitigates Glucocorticoid InducedDecreases in Prostaglandin Synthesis

摘要

The glucocorticoid dexamethasone (Dex) induces a decline in protein synthesis andprotein content of tissue cultured, avian skeletal muscle cells, and this atrophy is attenuated by repetitive mechanical stretch. Since the prostaglandin synthesis inhibitor indomethacin mitigated this stretch attenuation of muscle atrophy, the role of prostaglandins as growth modulators in these processes was examined. Dex