Support: Letter from Dupont to USEPA Reporting Additional Findings for Prior Submissions (Dated 9/91, 5/92, 9/01, 12/01 and 1/02) dated 04/04/2002

摘要

Groups of 10 male and 10 female Crl:CD(SD) IGS BR rats per dose group were administered the test compound through the diet. Test concentrations were 0, 10, 50 and 150 mg/kg body weight/day. The test was conducted in accordance with OECD Protocol 408. In-life phase evaluations included clinical observations, detailed physical examinations, sensory reactivity and grip strength, motor activity, body weight changes, food and water consumption and ophthalmic, hematologic and biochemical examinations. Macroscopic pathology was conducted on a variety of organ tissues from all the test animals. Histology was performed on all the animals that died or were killed prematurely, on all terminal animals in the control and high dose groups and on abnormal tissues from animals in the low and intermediate dose groups.