Kernel Principle Componenet Analysis of Microarray Data. (Report for September 1, 200-August 31, 2002);Final rept

摘要

Given the limitations in the quantity and quality of gene expression array data, the focus of the research was shifted to development of statistical and computation, I tools for evaluation and detection of disease susceptibility mutations within a large set of individuals or even an entire population. The diseases that are of particular interest are those with complex etiology, involving interaction of multiple genes and/or environmental factors. Such diseases (e.g., cardiovascular diseases, psychiatric illnesses, etc.) are common in the human population. Research towards the discovery of the genetic basis of these complex diseases is of major public health importance.