Biological Studies of Swine Exposed to 60-Hz Electric Fields. Volume 5. Hematology and Serum Chemistry. Final Report

摘要

The hematologic and serum chemistry responses in three generations of miniature swine chronically exposed to a 30-kV/m, 60-Hz electric field have been assessed in a series of screening experiments. Based on comprehensive analyses and sequential statistical evaluation of the data, there are no significant differences in any hematologic parameters in either the F sub 0 or F sub 1 generations when the exposed and sham-exposed groups are compared. In F sub 2 swine, at 42 days of age reticulocyte values were significantly higher in both sexes exposed to the electric field than in the control group. In addition, the exposed males at 42 days had significantly lower values for erythrocytes, hemoglobin and volume of packed red cells than the control males. Other values were comparable between exposed and control groups. Serum chemistry evaluations between exposed and control groups also showed no consistent statistical differences. A few parameters did show occasional differences between groups in the F sub 1 and F sub 2 generations, including: higher levels of urea nitrogen, triglyceride and alkaline phosphatase in exposed F sub 1 piglets; significantly lower serum protein levels in exposed F sub 2 males; and fewer serum globulins in both sexes of the F sub 2 generation. In summary, when hematologic and serum chemistry parameters were compared in exposed and sham-exposed groups of swine, some sporadic effects were evident. These effects, however, failed to replicate consistently at subsequent sampling periods or across generations and were not present as statistical trends when appropriate multivariate analyses were performed. 28 refs., 89 figs., 6 tabs. (ERA citation 11:012021)