Ultrastructure and Function of Erythrocyte Membrane Skeleton.

摘要

The membrane of the human erythrocyte is reinforced along its entire cytoplasmic surface by a two-dimensional network of peripheral proteins that closely adhere to the membrane proper through specific protein-protein interactions. This protein network resembles a shell that retains the approximate size and shape of the membrane ghost and is generally termed the skeleton. Spectrin, the major constituent of the membrane skeleton, accounts for approximately 75% of the skeletal protein mass. The molecular structure of spectrin is discussed in this paper. (ERA citation 13:037863)