Endogenous Retrotransposable Gene Elements AF Human Genome in High Incidence Cancers: Foreign Trip Report, December 6, 1988-March 6, 1989.

摘要

The traveler worked full time for 3 months at the new biomedical research institute of Academia Sinica to investigate the presence of mobile gene elements (retrotransposons and/or endogenous retroviral genes) in Chinese patient-derived hepatomas, nasopharyngeal cancers and cervical cancers. The research project, taking advantage of the traveler's unique expertise in this field of research and the collections of unique cancer cell/tissue materials at IBMS, is important for the development of a unique research project of human genome studies at ORNL. The traveler was successful in preparing five cDNA libraries of the Chinese patient origin (two from hepatomas and one each from nasopharyngeal cancer, cervical cancer and pituitary tumor); in obtaining preliminary results of human cancer cell poly(A) RNAs with tRNA primer binding and reverse transcription activities; in collecting cancer and normal chromosomal DNA materials from Chinese patients; and in establishing contacts for possible collaborative clinical and epidemiological investigation.