Functional Significance of the CSVTCG-Specific Receptor in Breast Carcinoma Progression.

摘要

We have isolated a novel CSVTCG-specific tumor cell adhesion receptor and shown by immunohistochemical staining of human breast tumors that the receptor localizes to malignant ductal epithelium while no staining of epithelium in normal and benign tissues was observed. Preliminary studies suggest that the CSVTCG-specific receptor may function to promote the invasive behavior of breast epithelium and contribute to the development of malignancy. To test this hypothesis, we propose to transfect tall-length receptor cDNA in the sense or antisense orientation in order to either over-express or block receptor expression in breast carcinoma cell lines. We will use vector constructs that constitutively express the green fluorescent protein in order to enable localization of tumor cells in our animal studies.